Creatine kinase is a dimer occurring in various in three isoenzymic forms, depending on the particular combination of its non-identical subunits:BB(brain type);MM(skeletal type); and MB(hybrid type). Creatine kinase-MB isoenzyme is released into circulation later than myoglubin, reaching abnormal levels within 4 to 6 hours after onset of symptoms,it reaches its highest level with a typical range of 39-185 ng/ml after about 18 to 24 hours,and returns to normal in about 2 to 3 days.CK-MB is widely recognized as the traditional marker for the diagnosis of acute myocardial infarction (AMI).
QuickProfile™ CK-MB Test Card is a sandwich immunoassay. When serum sample is added to sample pad, it moves through the conjugate pad and mobilizes gold anti-CK-MB conjugate that is coated on the conjugate pad. The mixture moves along the membrane by capillary action and reacts with anti-CK-MB antibody that is coated on the test region. If CK-MB is present at levels of 7.0 ng/ml or greater, the result is the formation of a colored band in the test region. If there is no CK-MB in the sample, the area will remain colorless. The sample continues to move to the control area and forms a pink to purple color, indicating the test is working and the result is valid.
QuickProfile CK-MB (Whole Blood)
29 Forest Road, Piddington, Northampton. NN7 2DA
Tel. (01604) 870370 Fax (01604) 870194